Background: KRAK Study is a Polishmulti-centre patch test study utilizing the new Polish Baseline Series (introduced in June 2010), which basically consists of European Baseline Series supplemented with two frequent and relevant sensitizers palladium and propolis.
Objectives: To analyse KRAK Study patch test results with the new Polish Baseline Series.
Methods: Eleven participating dermatology and allergy centres submitted data of patients tested to the Polish Baseline Series (Chemotechnique Diagnostics) from June 2010 until October 2011.
Results: Altogether, 624 patients (475 women and 149 men aged 0 to 85,median 36 years)were patch tested in participating centres. At least one positive reaction was recorded in 370 patients (59.3%). In 255 patients (40.9%), at least one positive test was deemed clinically relevant (higher rates in children and adolescents: 65.4% and 46.5%, respectively). The top 16 sensitizers were nickel (33.5% positive;24.7% deemed clinically relevant), cobalt (16.2% and 8.3%, respectively), chromium (14.7%; 7.1%), palladium (11.4%; 4.2%), paraphenylenediamine (7.4%; 3.8%), balsam of Peru (6.6%; 2.7%), fragrance mix I (6.3%; 3.4%), propolis (4.6%; 1.4%), fragrance mix II (3.4%; 1.6%), neomycin (3.4%; 1.0%), wool alcohols (2.6%; 1.4%), colophonium(2.4%;1.6%), lyral (2.4%;1.1%)MI/MCI0.01%(2.1%; 1.6%), paraben mix and primin (each 1.9%; 1.1%). Noteworthy, the two additions to the Polish Baseline Series - palladium and propolis occupied ranks 4 and 8, respectively. Also interestingly, 10 patients (1.6%) reacted to palladium, but not nickel, suggesting that under modern environmental exposures palladium is not just a mere cross-reactivity to nickel, as commonly believed.
Conclusion: Polish patients are most frequently sensitized to metals and cosmetic ingredients. Natural remedies containing balsam of Peru and propolis should be avoided because of high sensitization rates. Our results confirm that palladium and propolis are frequent sensitizers and are important additions to the baseline patch test series.
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Document created: 8 July 2012, last updated: 9 July 2012.