Drug intolerance among young Poles

Radoslaw Spiewak1, Andrzej Horoch2

1Institute of Dermatology, Krakow (Poland)
2Medical Academy, Lublin (Poland)

Source: Spiewak R, Horoch A. Drug intolerance among young Poles. J Invest Dermatol 2006; 126 (Suppl 3: 36th Annual European Society for Dermatological Research Meeting Paris, France, 7-9 September 2006): s68 (Abstract 394).

Background: During a nationwide study of vocational students' health status, history of drug intolerance was collected in a random sample of the population tested.

Methods: 134 Polish vocational students (51 females and 83 males), aged 16-23 (median 19) years underwent medical health checks, including skin prick tests with common allergens, total IgE measurement and Phadiatop test. The physician-administered questionnaire included a question about symptoms of drug intolerance ("Have you ever had adverse reactions after taking any medicine?"). In case of a positive answer, the trade name or at least category of the causative drug was recorded whenever possible.

Results: The question about drug intolerance was answered positively by 13 persons, which makes 9.7% of the population examined (95%CI: 4.7-14.7%). Among them, 9 persons had intolerance reactions to antibiotics (5 to penicillin, 1 to doxycyclin, 1 to cefadroxil and 2 to unspecified antibiotics). Four persons complained of ASA-intolerance and 2 persons of intolerance to pyrazolone drugs (metamizole and amimophenazone). There was no significant correlation between drug intolerance in the patients' history and gender (Fisher's chi-square exact test: p1=0.08 for all drugs and p2 = 0.30 for antibiotics), IgE level (p1=1.00 and p2=1.00 respectively), Phadiatop test result (p1=0.75, p2=0.47), atopy defined as combination of IgE, Phadiatop and skin prick test results (p1=0.38, p2=0.23), history of dermatitis (p1=0.19, p2=0.27), history of allergic rhinitis (p1=0.51, p2=1.00) as well as history of asthma (p1=0.13 and p2=0.07).

Conclusion: 5-15% of young Poles had at least one episode of drug intolerance in their lives.

Poster (PDF)

Links:

Institute of Dermatology - diagnosis of drug allergy

Celimun biomedical research of drug allergy

ELISpot.biz - training and implementation

ELISpot.biz - scanning and analysis of ELISpot plates

immunologia.BIZ - odczynniki i aparatura: ELISpot, ELISA, cytometria

Celimun - alergia na leki - badania

Specjalista dermatolog i wenerolog, Kraków

© Radoslaw Spiewak. (contact).
This page is part of the www.RadoslawSpiewak.net website.
Document created: 29 August 2006, last updated: 1 September 2007.